A numerical model called PICASSO [Production d'Ions Corona Au Sol Sous Orage (French) and Production of Corona Ions at the Ground Beneath Thundercloud (English)], previously designed, is used to describe the evolution of the principal electrical parameters below a thunderstorm, taking into read more account the major part played by corona ions
The Effects Doctrine creates an important basis for the application of local law outside of its territory.It reflects the understanding that in this day and age, actions taken in one jurisdiction can significantly affect other jurisdictions.The use of competition law extraterritorial jurisdiction, based on the effects doctrine, has long been debate
There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo.Here, by using the multi-protein tip complex of the mannose-binding type 1 fimbriae of Escherichia coli, we sho
Since the rapid outbreak of Covid-19, profound research interest has emerged to understand the innate immune response to viruses to enable appropriate vaccination.This understanding can help to inhibit virus replication, prolong adaptive immune response, accelerated virus clearance, and tissue recovery, a key milestone to combat coronaviruses (CoVs
Abstract Background There is increasing interest in enhancing the response of the PARP inhibitor olaparib, which is currently approved for pancreatic ductal adenocarcinoma (PDAC) patients with defects in DNA damage repair associated with germline BRCA1/2 mutations.Moreover, agents that can mimic these defects in the absence of germline BRCA1/2 muta